Every year, thousands of people face cancer diagnosis. Survival rates are high, but many face devastating disabilities and long-term side effects resulting from currently treatments. Sirtuins (SIRT) regulate many key processes in cells, including their metabolism, health & death and shutting down genes that promote cancer growth, amongst its many roles.
In cancerous cells, SIRT’s activity can be compromised and modulation of it shows to produce anticancer activity. We have designed a “smart” biomolecule (aptamer) that has shown that selective modulation of SIRT in cancerous cells produces cell death and shows no toxicity on non-cancerous cells.
In this cell / molecular biology project, we will expand the biological studies of the modulation of the SIRT family with the aim of finding new targets downstream and producing new therapies. This is an exciting opportunity to identify new targets, we are looking to recruit a PhD student with a relevant biological, chemical or biomedical science background to study biological mechanisms and new therapies to treat cancer.
You will: • Develop practical cell biology skills in cell culture, mechanism elucidation and toxicology, • Develop practical skills for imaging and analysis, • Develop transferable skills such as reporting results, data presentation, time management and project planning.
You will be working at the interface between chemistry and biology, gaining scientific papers. The results of this PhD project have the potential of identifying new targets in cancer therapy.
Funding Notes: Self-Funded Students only
Please quote the studentship number when applying - ISTM2019_06