Stimulating the sirtuin family in the treatment of inflammatory diseases”

Cancer and ageing are interconnected through inflammation. Continuous exposure of internal and external stressors on cells can lead to a cancer diagnosis. Survival rates in cancer might be high, but many patients face devastating disabilities and long-term side effects resulting from currently treatments.

Sirtuins (SIRT) regulate many key processes in cells, including their metabolism, health & death and shutting down genes that promote cancer growth, amongst its many roles. This family is key in modulating inflammation, cancer, and aging. In cancerous cells, SIRT’s activities can be compromised and modulation of it shows to produce cell death. We are studying the selective modulation of SIRT in cancerous and non-cancerous cells.

In this cell / molecular biology project, we will expand our knowledge on the modulation of the SIRT family with the aim of finding new targets downstream and producing new therapies. This is an exciting opportunity to identify new targets, we are looking to recruit a PhD student with a relevant biological, biochemistry, biomedical, chemical, pharmacy, pharmacology or science background to study biological mechanisms and new therapies to study and treat cancer.

In this project you will:

·        Develop practical cell biology skills in cell culture, and mechanism elucidation,

·        Develop practical skills for imaging and analysis,

·        Develop transferable skills such as reporting results, data presentation, time management and project planning.

Please quote FMHS_PR2OCT2022 on your application.