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Stimuli-responsive proteins for nanobiotechnology applications


   School of Biological Sciences

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  Dr M Soloviev, Dr E Ferrari  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Research into stimuli-responsive polymers and biopolymers over last few decades generated substantial body of published literature. Nanoparticles, polymers and proteins with engineered pH, redox, temperature, light or combinations of sensitivities have been explored for stimuli-responsive drug delivery, diagnostics and a multitude of molecular sensors applications. Voltage-sensitive proteins, such as voltage activated ion channels, are abundant in nature. But few if any molecular actuators, capable of transducing electromagnetic signals directly to biochemically meaningful outputs, rather than to affect ion channels in cellular membranes have been discovered.

This projects aims to further this research and to engineer proteins with real-time sensitivity to electromagnetic fields. Such capability could allow us to modulate protein functions in the locality of the electromagnetic actuator and ultimately to create functional “hard-soft” interface between protein molecules and a computer. Such capability will greatly benefit biotechnology, for example by providing electrically controllable protein actuators for Lab-on-a-Chip or similar nanobiotechnology applications. The project will utilize a range of biochemical, biophysical, analytical and instrumental techniques. Necessary training will be provided.

We welcome candidates with a keen interest in protein engineering and nanotechnology and preferably with a research background in either biochemistry, biophysics or related disciplines. You should have (or expect to attain) a First class BSc or MSc in a relevant discipline.

Interested applicants are invited to send their detailed CV and a short cover letter explaining your motivation by email to [Email Address Removed] and [Email Address Removed]

The latest project start date is September 2022. Part-time registration and alternative start date are possible, please indicate your preferences.

References:

https://pure.royalholloway.ac.uk/portal/person/mikhail.soloviev

https://staff.lincoln.ac.uk/192e6ff2-03ee-4dd6-9eed-c5240bdeebf1


References



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