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Stress regulation of protein translation: role in cancer and neurodegeneration


Project Description

Cells are subjected to a range of stresses that include physical injury, changes in oxygen levels or temperature, nutrient deprivation, radiation and infection. They respond by triggering stress-signalling pathways that act to maintain homeostasis. Disruption of these pathways can lead to developmental abnormalities and diseases including cancer and neurodegeneration, as well as affecting the rate of ageing. We are interested in how stress affects protein translation and the impact on cellular function and health. In particular, we are investigating how the dynamics of protein translation are regulated by the formation of intracellular bodies called stress granules and how this process is controlled by the actions of key intracellular signalling pathways, including the TOR pathway. This research will enhance our understanding of the cellular mechanisms that underpin stress-related pathologies and contribute to efforts to combat these.

Approaches used will include mammalian cell culture, C. elegans transgenics, recombinant protein expression, mutagenesis, immunoblotting and immunoprecipitation, fluorescence microscopy, RNAi, CRISPR gene editing and genomics.

Entry Requirements
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject.

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor.

Funding Notes

Applications are invited from self-funded students. This project has a Band 3 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

References

Sfakianos, A. et al. (2016) Biochem Soc Trans 44: 1411-1416.

Protter, D. and Parker, R. (2016) Trends Cell Biol 26: 668-679.

Anderson, P. et al. (2015) Biochim Biophys Acta 1849: 861-870.

Vanderweyde, T. et al (2013) Gerontology 59: 524-533.

Thedieck et al. (2013) Cell 154: 859-874.

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