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  Structural and Computational Studies of the IRF4-DNA regulatory interactions in Multiple Myeloma


   School of Life Sciences

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  Dr E Mancini  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

We are seeking a motivated and experienced PhD student to join our team in the Department of Biochemistry at the University of Sussex. The studentship will focus on the structural and functional characterization of transcription factors involved in Multiple Myeloma.

Multiple Myeloma is an aggressive cancer of plasma cells, which are a type of white blood cell. The disease is characterized by the overproduction of monoclonal antibodies, which are proteins that are produced by a single cell type. Multiple Myeloma is incurable and new treatments are urgently required.

The student will use a combination of biochemical, biophysical, and structural biology techniques to study the interaction between proteins and DNA. The student will also use computational modelling to study the impact of DNA interactions on the expression of target genes.

The successful candidate will have a strong background in molecular biology and biochemistry and experience in protein expression and purification is essential. Experience in structural biology and computational modelling is desirable but not necessary. The student will be able to work independently and as part of a team.

How to apply:

Please submit a formal application through the online admissions portal attaching a CV, degree transcripts and certificates, statement of interest and two academic references.

On the application system select Programme of Study – PhD Biochemistry. Please ensure you state the project title under funding and obtained include the supervisor’s name where required. No research proposal is required.

The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.

For enquiries about the project, please contact supervisor: [Email Address Removed]


Biological Sciences (4)

Funding Notes

This School-funded position covers Home (UK) tuition fees and a stipend at standard UKRI rates for 3.5 years. Applicants with overseas fee status need to provide evidence showing how they will fund the difference between Home and International tuition fees (approx. £18k per year).
Ideal candidates will have a strong background in Biochemistry and Protein Purification. Eligible applicants will hold a 2:1 BSc in a relevant subject. Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section.

References

1) Agnarelli A, Mitchell S, Caalim G, Wood CD, Milton-Harris L, Chevassut T, West MJ, Mancini EJ. Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4-MYC oncogenic axis in multiple myeloma. Hematol Oncol. 2022 Aug;40(3):417-429. doi: 10.1002/hon.3016.
2) Agnarelli A, Chevassut T, Mancini EJ. IRF4 in multiple myeloma-Biology, disease and therapeutic target. Leuk Res. 2018 Sep;72:52-58. doi: 10.1016/j.leukres.2018.07.025.

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