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Structural and functional studies on ciliary proteins required for vision

Project Description

Rod and cone photoreceptor cells in the retina detect light, allowing us to see. When specialised cellular structures in photoreceptors are disrupted, this is a major cause of childhood and adult-onset blindness. These cellular structures are targeted in several clinical trials for several inherited retinal conditions, but our poor understanding of their organization and function limits the development of new therapies. You will grow relevant retinal cells and tissues (photoreceptors in retinal organoids) from stem cells, and then use them for cutting-edge techniques in structural biology and imaging. You will solve molecular structures of key retinal proteins and then place these structures into their cellular context in photoreceptors. Understanding cellular organisation is an exciting new frontier in biology, and the studentship provides opportunities for superb training in techniques that span structural biology and stem cell biology. The research also has direct medical relevance, informing the design of new targeted therapies. This work builds on successful projects between the Astbury Centre for Structural Molecular Biology, University of Leeds, and Leeds Institute of Medical Research. The Astbury Centre is a major hub for structural biology in the UK, with world-class facilities and a vibrant, highly interdisciplinary research environment.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2020:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference and research funding

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.

EU candidates require 3 years of UK residency to receive full studentship

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How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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