Structural and mechanistic studies of fibroblast growth factor receptor signalling


   Faculty of Biological Sciences

  ,  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25.

We have identified a previously undiscovered ‘signal switching’ mechanism used by a branch of the receptor tyrosine kinase (RTK) family – fibroblast growth factor receptors (FGFRs) – that are important in early development but also oncogenic in a range of cancers.

The allosteric molecular switch that we’ve found triggers an order-to-disorder transition within the kinase domain, revealing a cryptic binding site for PI3 kinase. Conservation of this cryptic binding motif across RTKs suggests wider physiological relevance well beyond the FGFRs themselves.

In this project you will join a vibrant and stimulating research environment within the renowned Astbury Centre for Structural Molecular Biology at the University of Leeds. You will work alongside others in the Breeze and Sobott labs, as well as our collaborator’s lab at University College London (UCL).

As a candidate, you will preferably have an interest in, and aptitude for, structural molecular biology and computational and biophysical analysis. This is primarily a structural biology project in which you will learn and use cutting-edge techniques including NMR, HDX mass spectrometry, EPR, and X-ray crystallography, plus the accompanying computational skills. You will have access to the Astbury Biostructure Laboratory’s world-class infrastructure including ultra-high field NMR (cryoprobe-equipped 950 MHz Bruker Avance III HD) and structural mass spectrometry (Waters Synapt G2 with HDX plus Thermo Orbitrap UHMR). You will also become proficient in kinase assays and biophysical techniques including ITC and SPR. Via collaboration with our UCL colleague, you will also learn fluorescent cell imaging techniques.

Eligibility

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline.

Applicants whose first language is not English must provide evidence that their English language is sufficient to meet the specific demands of their study. The Faculty of Biological Sciences minimum requirements in IELTS and TOEFL tests are:

  • British Council IELTS - score of 6.0 overall, with no element less than 5.5
  • TOEFL iBT - overall score of 87 with the listening and reading element no less than 20, writing element no less than 21 and the speaking element no less than 22. 

How to apply

To apply for this project applicants should complete an online application form and attach the following documentation to support their application. 

  • a full academic CV
  • degree certificate and transcripts of marks
  • Evidence that you meet the University's minimum English language requirements (if applicable)
  • Evidence of funding

To help us identify that you are applying for this project please ensure you provide the following information on your application form;

  • Select PhD in Biological Sciences as your programme of study
  • Give the full project title and name the supervisors listed in this advert

For information about the application process please contact the Faculty Admissions Team:

e:

Biological Sciences (4) Chemistry (6)

Funding Notes

This project is open to applicants who have the funding to support their own studies or who have a sponsor who will cover these costs.

How good is research at University of Leeds in Biological Sciences?


Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Register your interest for this project



Where will I study?

Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.