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Structural characterization of nucleic acid modifying enzymes


Project Description

DsRNA within the cell can be of viral origin or can be endogenous. Therefore it is important to distinguish between them as otherwise this could result in inappropriate activation of the innate immune sensors that could lead to auto immune diseases. This proposed project is to purify proteins that are components of the innate immune pathway, that bind to dsRNA and form complexes with it. These proteins will be epitope-tagged and over-expressed in the appropriate system. Characterization of their binding to dsRNA and to their complex formation with other proteins in the innate immune pathway will be elucidated.

Applicants who wish to pursue a degree at the CEITEC PhD programme must hold the equivalent of a Master’s degree (MSc) in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five month after the application deadline.

All general enquiries should be directed to Olga Krizova (). Scientific inquiries can be addressed to the supervisor ().

Funding Notes

Admission for studies, student registration for the full-time study programme and proper fulfilment of student duties constitute the student’s right to a regular scholarship of 22 000 CZK (850 EUR). Information is available at View Website

Living costs and other practicalities available at View Website

References

1 Mannion, N. M. et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep 9, 1482-1494, doi:10.1016/j.celrep.2014.10.041 (2014). 2 Rice, G. I. et al. Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. Nature genetics 44, 1243-1248 (2012).

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