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Structural insights into signaling complexes of the MAPK pathway

Project Description

Cellular signaling is a key process that mediates the translation of an extracellular or intracellular signal to cause responses such as proliferation, differentiation, migration or cell death. One of the key pathways is the mitogen activated protein kinase (MAPK) pathway. The MAPK pathway is involved in a variety of fundamental cellular processes activated by a diverse set of stimuli. Dysregulation of the MAPK pathway has been implicated in the development of many human diseases, including cancer. Cellular signalling stimulates the formation of protein complexes that positively and negatively regulate the activation of the pathway. Although the MAPK pathway has been extensively studied, little is know about the formation of these protein complexes and how the intricacies of protein interactions can modulate signalling.
This PhD will use cryo-electron microscopy and x-ray crystallography in the newly established £15M Astbury Biostructure Laboratory to structurally characterise protein complexes. The is based in the laboratory of Dr Tomlinson and will be part of a large team consisting of 20 people including PDRAs, PhD, MRes, technicians and undergraduate students who all utilise Affimer reagents for studying protein function in disease. You will also work in the laboratories of Dr Ranson and Dr Zeqiraj, who are world-leading experts in structural biology.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2020:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference and research funding

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.

EU candidates require 3 years of UK residency to receive full studentship

Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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Related Subjects

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

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