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Structural, Molecular and Cellular Biology of Negative Stranded RNA Viruses.


   Faculty of Biological Sciences

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  Dr J N Barr  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Negative stranded RNA viruses include many serious human pathogens including respiratory syncytial virus, rabies virus, Crimean-Congo hemorrhagic fever virus, and Ebola virus. We study the structural, molecular and cellular biology of many of these viruses, in order to find new ways of combatting the diseases they cause. We are able to offer several projects on these virus systems to outstanding students. These projects range from eludidating crystal structures of critical virus proteins, understanding how these viruses express their limited genetic information, and figuring out how they interact with the host to remodel the cellular environment to suit their own means.

Funding may also be available through a recently announced University Aniversary Research Scholarship Scheme, that provides all fees and a stipend for 3 years. See the following link for more details: http://www.fbs.leeds.ac.uk/gradschool/keywords/mnuFindaphd.php

Funding Notes

Applications from highly qualified individuals are invited, and further details of PhD topics are available on request. Candidates are expected or predicted to possess either a first-class or upper second-class degree in a related topic, or equivalent. Students are required pay registration fees at rates set by the University, as well as bench fees that will depend on the topic of study. Please contact the supervisor by email

References

Carter SD; Surtees R; Walter CT; Ariza A; BergeronÉ; Nichol ST; Hiscox JA; Edwards TA; Barr JN Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. Journal of Virology, 86 10914-10923, 2012

Tanner S. J., Ariza, A., Richard, C. A., Kyle, H. F., Dods, R. L., Blondot, M. L., Wu, W., Trincão, J., Trinh, C. H., Hiscox, J. A., Carroll, M. W., Silman, N. J., Eléouët, J-F., Edwards, T. A., Barr, J. N. Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. (2014) Proc Natl Acad Sci U S A. Jan 28;111(4):1580-5.

Ariza, A., Tanner, S. J., Walter, C. T., Dent, K. C., Shepherd, D. A., Wu, W., Matthews, S. V., Hiscox, J. A., Green, T. J., Luo, M., Elliot, R. M., Fooks, A. R., Stonehouse, N. J., Ranson, N. A., Ashcroft, A. E., Barr, J. N., Edwards, T. A. (2013). Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization. Nucleic Acids Research, Epub April 17th
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