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  Structural Studies on single-stranded RNA viruses and their complexes with receptors

   Faculty of Biological Sciences

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  Prof N A Ranson, Prof P G Stockley  No more applications being accepted  Competition Funded PhD Project (European/UK Students Only)

About the Project

Single-stranded RNA viruses are major pathogens in all kingdoms of life, causing widespread misery and death in human populations worldwide and extensive damage in agriculture. We are interested in two aspects of their lifecycles. Firstly, we have discovered a previously unsuspected assembly mechanism that explains how they specifically package their genomic RNAs into viral particles when the cell is full of potentially competing mRNA. Secondly we are studying the earliest steps in infection as the RNA is released from such particles. We will address these questions by determining the structures of viruses, virus-like particles and virus-receptor complexes using cryo-electron microscopy.

Funding Notes

4 year BBSRC studentship, under the White Rose Mechanistic Biology DTP.
The successful applicant will receive fees and stipend (c.£13726 for 2014-15). The PhD will start in Oct 2014. Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support.
There are 2 stages to the application process. Please see our website for more information:

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