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Structural study of enterovirus replication in vivo

  • Full or part time
  • Application Deadline
    Friday, March 15, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Viruses from the Enterovirus genus belong to the family Picornaviridae of human and vertebrate pathogens. Diseases caused by enteroviruses range from upper and lower respiratory tract infections to life-threatening encephalitis. Rhinoviruses are responsible for 40% of the common cold cases that result in yearly cost of tens of billions of US$ in treatments and lost working hours worldwide.
The student will study the replication cycle of enteroviruses (represented by human rhinoviruses A2 and B14 and enterovirus 71) in vivo by a combination of focused ion beam milling and cryo-electron tomography. He/she will investigate the mechanism of enterovirus genome release and delivery into a host cell, changes in intra-cellular organization induced by enterovirus infection, and the assembly of progeny virions. We will complement the whole-cell studies by high-resolution cryo-electron microscopy of virus genome release under biologically relevant conditions in vitro.

Keywords: enteroviruses, replication cycle, ion beam milling, cryo-electron tomography, cryo-ET, cryo-electron microscopy, virology

Applicants who wish to pursue a degree at the CEITEC PhD programme must hold the equivalent of a Master’s degree (MSc) in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five month after the application deadline.

Funding Notes

Admission for studies, student registration for the full-time study programme and proper fulfilment of student duties constitute the student’s right to a regular scholarship of 22 000 CZK (850 EUR). Information is available at View Website

Living costs and other practicalities available at View Website

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