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Structure and function of CIZ1/RNA complexes

  • Full or part time
    Dr D Coverley
  • Application Deadline
    Sunday, January 05, 2020
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

X chromosome inactivation (XCI) serves as a model for establishment and
maintenance of selective transcriptional silencing throughout the genome.
The nuclear matrix protein Cip1-interacting zinc finger protein 1 (CIZ1) plays
a role in DNA replication in association with cyclins, and is linked with adult
and paediatric cancers. CIZ1 is recruited to the inactive X chromosome (Xi) in
female cells in a manner dependent on the archetypal long non-coding RNA
(LNCRNA) Xist, while retention of Xist at Xi is dependent on CIZ1 in somatic
cells, suggesting co-dependency. Recent data argue for a role in
maintenance of chromatin state during Xi replication in S phase of the cell
cycle. This project will investigate the requirements for and mechanism of
retention and release of CIZ1-Xist particles at Xi. It will use a range of
molecular, cellular and structural biology techniques, including mammalian
cell culture and cell cycle analysis, cell-free reconstitution of regulated events,
high resolution imaging, X-ray crystallography and cryo-EM, with scope to
develop the project in a number of ways.

Funding Notes

This studentship is fully funded for four years and covers: (i) a tax-free annual stipend at the standard Research Council rate (£15,009 estimated for 2020 entry), (ii) research costs, and (iii) tuition fees at the UK/EU rate.


Entry requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this research project means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions.

How good is research at University of York in Biological Sciences?

FTE Category A staff submitted: 44.37

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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