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Structure, dynamics and interactions of Microtubule Associated Protein 2c and bacterial RNA polymerase subunits and sigma factors


Project Description

Microtubule associated protein 2c (MAP2c) is a key factor regulating microtubule dynamics in developing brain neurons, and an example of an intrinsically disordered proteins with an important physiological function and detectable structure-function relationship. The first goal is to study MAP2c in a natural complexity and by methods providing atomic resolution. Such methods include paramagnetic relaxation interference, to detect and describe transient local structures of MAP2c important for its function, and real-time NMR, to monitor kinetics of MAP2c phosphorylation by relevant kinases of different signalling pathways. The second goal is to characterize interactions of MAP2c with biologically important binding partners, especially with isoforms and a monomeric form of regulatory protein 14-3-3. The third goal is to test the effect of cellular environment on MAP2c by recording NMR spectra at near-to-native conditions (in cells and/or cell lysates) and/or by performing cryo-electron tomography on monolayered neurons.
The applicant may focus on one of these areas
Interactions underlying physiological function of Microtubule Associated Protein 2c
Structure, dynamics and interactions of bacterial RNA polymerase subunits and sigma factors

Keywords: Microtubule Associated Protein 2c, MAP2c, NMR spectroscopy, cryo-electron tomography, 14-3-3 protein, RNA polymerase, transcription, bacteria, nuclear magnetic resonance
Microtubule Associated Protein 2c, MAP2c, NMR spectroscopy, cryo-electron tomography, 14-3-3 protein

HOW TO APPLY: Register for this call using the registration form at http://ls-phd.ceitec.cz/http-ls-phd-ceitec-cz/ and submit required documents to receive support with the preparation of the application and all formalities. Your application package will be forwarded to the supervisor for preliminary revision.
Applicants who wish to pursue a degree at the CEITEC PhD program must hold the equivalent of a Master’s degree (MSc) in a similar field (four- or five-year undergraduate degree). The application can be submitted before obtaining the Master’s degree; however, the applicant should obtain a degree within five months after the application deadline.

Funding Notes

Admission for studies, student registration for the full-time study program, and proper fulfillment of student duties constitute the student’s right to a regular income of 22 000 CZK (850 EUR). Information is available at View Website
Living costs and other practicalities available at View Website

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