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Structure, dynamics and interactions of subunits of RNA polymerase of Gram-positive bacteria

Project Description

Certain RNA polymerase subunits (including sigma factors) are specific for Gram-positive bacteria. Such subunits are critical determinants of the enzyme specificity for DNA promoter sequence. Structures of delta subunits and of the vegetative sigmaA 1.1. domain, both containing highly dynamical regions, have been solved and further characterized in the group. The results suggest an important role of the conformational flexibility in functions of the subunits, but mechanistic details remain to be revealed. The aim of the thesis is to study dynamics and interactions of the subunit in order to understand their roles on the atomistic level, and provide structural data for other sigma factors and/or their domains. Standard and advanced methods of nuclear magnetic spectroscopy, recently developed in the group for such applications, will be combined with X-ray crystallography and cryo-electron microscopy

Keywords: Gram-positive bacteria, RNA polymerase subunits, NMR spectroscopy, X-ray crystallography, cryo-electron microscopy

Applicants who wish to pursue a degree at the CEITEC PhD programme must hold the equivalent of a Master’s degree (MSc) in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five month after the application deadline.

Funding Notes

Admission for studies, student registration for the full-time study programme and proper fulfilment of student duties constitute the student’s right to a regular scholarship of 22 000 CZK (850 EUR). Information is available at View Website

Living costs and other practicalities available at View Website

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