Structure formation and functions in hybrid lipid-polymer electrospun membranes

The aim of this project is to investigate the structure-related functions of biomimetic lipid-polymer hybrid nanofibre membranes. The nanofibers’ morphology will be controlled during electrospin processing and by incorporation of lyotropic liquid crystalline (LLC) phases. Namely, bicontinuous cubic phase comprised of intertwined channels network, hexagonal phase with tubular-shaped structures or planar lipid self-assemblies will be incorporated within the polymer fibres. Nanomechanical properties will be investigated by in-situ X-ray scattering, tensile and complementary imaging techniques. The project will then explore interactions of adipocytes and skeletal muscle cells with the nanofibre membranes and their control of cellular growth and patterning. The work will therefore contribute to innovative engineering of functional materials for a wide range of applications, including biomedical scaffolds, implants, coatings and cultured meat products.