About the Project
See https://www.bioc.cam.ac.uk/mottowen for more information about our work and publications.
Applications should be sent to Helen Mott ([email protected]), including a CV detailing academic achievements so far, a motivational statement and the names and contact details of two referees.
C. L. Hutchinson, P.N. Lowe, S.H. McLaughlin, H.R. Mott & Owen D (2013). Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB. Biochemistry. 52 7999-8011
L. J Campbell, M. Peppa, M.D. Crabtree, A. Shafiq, N.F. McGough, H.R. Mott & D. Owen (2015) Thermodynamic mapping of effector protein interfaces with RalA and RalB. Biochemistry. 54 1380-1389
H.R. Mott & D. Owen (2015) Structures of Ras superfamily effector complexes: What have we learnt in two decades? Crit Rev Biochem Mol Biol. 50 85-133.
J.R. Watson, H.M. Fox, D. Nietlispach, J.L. Gallop, D. Owen D & H.R. Mott (2016) Investigation of the interaction between Cdc42 and its effector TOCA1: handover of Cdc42 to the actin regulator N-WASP is facilitated by differential binding affintiies. J. Biol. Chem. 291 13875-13890.
J.C. Thomas, J.M. Cooper, N.S. Clayton, C. Wang, M.A. White, C. Abell, D. Owen & H.R. Mott (2016) Inihibition of Ral GTPases using a stapled peptide approach. J. Biol. Chem. 291 18310-18325.
H.R Mott & D. Owen (2018) Bioblockades join the assault on small G protein signalling. (2019) Semin Cancer Biol 54 149-161
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