About the Project
This hypothesis calls for the need to be creative and develop a new experimental, computational and theoretical framework. To this end, we will use match diagnostic relapse/resistant patient’s samples and improved preclinical models including patient derived tumour xenografts (PDXs) to identify transcription factor activity shifts and other non-genetic regulatory factors dynamics. This work will involve chromatin immunoprecipitation, genomic and single-cell transcription analysis exploiting in vivo and ex vivo improved patient-derived preclinical models developed in the lab. Functional screens using CRISPR and/or drug screenings will be further used to complement and validate our effort towards deepening our understanding underlying drug-tolerant states and cancer progression dynamics.
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