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Study of enhancer and transcription factor dynamics underlying children’s aggressive solid cancer evolutionary processes

PhD Programmes

About the Project

We have an opportunity for a talented and motivated PhD fellow to focus on identifying enhancer and transcription factor dynamics underlying children’s aggressive cancer evolutionary processes. As a consequence of paediatric cancer cell’s addiction to its developmental origin, the major driving forces of adaptability in childhood cancers we hypothesize are evolutionary conserved cell-of-origin chromatin configurations of cell plasticity.

This hypothesis calls for the need to be creative and develop a new experimental, computational and theoretical framework. To this end, we will use match diagnostic relapse/resistant patient’s samples and improved preclinical models including patient derived tumour xenografts (PDXs) to identify transcription factor activity shifts and other non-genetic regulatory factors dynamics. This work will involve chromatin immunoprecipitation, genomic and single-cell transcription analysis exploiting in vivo and ex vivo improved patient-derived preclinical models developed in the lab. Functional screens using CRISPR and/or drug screenings will be further used to complement and validate our effort towards deepening our understanding underlying drug-tolerant states and cancer progression dynamics.

Funding Notes

Students receive an annual stipend, currently £21,000 per annum, as well as having tuition fees (both UK/EU and overseas) and project costs paid for the four-year duration. We are open to applications from any eligible candidates and are committed to attracting and developing the best minds in the world.

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