About the Project
1. Develop a microfluidic device consisting of multiple storage areas, separated by an array of posts and openings, which allows separation of offspring-worms from parent-worms.
2. Evaluate the effects of short- and long term nanoparticle exposure to worms and their progenies. We will study the survival rate, lifespan, growth, motility, biodistribution and reproduction of the animal on-chip, which depend on nanoparticle size, shape, and surface-functionalisation.
3. Investigate the impact of nanoparticles on C. elegans ageing of (i) the different types of particles, (ii) epigenetic effects, such as missense variants of the ryanodine receptor and consequences of chromatin modifications, through successive generations.
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