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Supramolecular Approaches to Drug Design and Delivery

  • Full or part time
  • Application Deadline
    Friday, February 28, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

UCL Chemistry Department is offering a fully funded studentship to a highly motivated candidate to start in September 2020.The student will carry out their doctoral research at UCL.

We are interested in the application of supramolecular chemistry to medicinal and biological fields. By controlling how a molecule interacts with its surroundings, we can translate existing chemical knowledge into new environments and access novel functions. For more information about the research interests of Dr Cally Haynes, please refer to:

This project will aim to engineer specific non-covalent interactions (such as hydrogen bonding, halogen bonding and chalcogen bonding) that can reversibly and controllably dictate the interactions of small molecules with their surroundings. We will apply this knowledge to gain control of the cellular uptake and biodistribution of small, functional molecules in order to design new therapeutics and diagnostics that need to be delivered to a particular site in order to function. We will also incorporate our new molecular designs into the controlled construction of functional amphiphiles to mediate specific processes at self-assembled interfaces.

This multidisciplinary project will provide opportunities to work at the interface of chemistry with biological and materials sciences and to collaborate with other researchers in these areas at UCL and further afield. The project will use techniques including advanced NMR and fluorescence spectroscopies, X-ray crystallography and the preparation and handling of model lipid bilayer systems.

The applicants should have, or be expecting to achieve, a first or upper second class Honours degree or equivalent in chemistry or a related subject. UK/EU students are eligible for this studentship, which will cover tuition fees at UK/EU rate plus a stipend (tax-free) for three years. We also welcome applications from self-funded students, or those who have alternative funding available.

The successful candidate should be able to work independently and have good communication skills. Curiosity and creativity are highly valued and underpin much of what we do. Prior experience in supramolecular chemistry, organic synthesis and/ or NMR analysis would be an advantage.

Interested candidates should initially contact supervisor Dr Cally Haynes () with a degree transcript and a motivation letter expressing interest in this project. Informal inquiries are encouraged. Suitable candidates will be required to complete an electronic application form at Any admissions queries should be directed to Dr Jadranka Butorac ().

Applications will be accepted until 28th February 2020 but the position will be filled as soon as a suitable candidate has been identified.

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