This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP). The DTP offers an interdisciplinary research training programme delivered by a consortium comprising the Universities of Bath, Bristol and Exeter, Cardiff University and Rothamsted Research, alongside six regional associate partners: Marine Biological Association, Plymouth Marine Laboratory, Swansea University, UCB Pharma, University of the West of England and SETsquared Bristol. The partnership has a strong track record in advancing knowledge through high quality research and teaching, in collaboration with industry and government. For more information about the DTP, see https://www.swbio.ac.uk/
Studentships are available for entry in September/October 2020.
All SWBio DTP projects will follow a structured 4-year PhD model, combining traditional project-focussed studies with a taught first year which includes directed rotation projects.
Overview of this PhD project:
Dr Mirella Di Lorenzo, Department of Chemical Engineering (University of Bath) https://researchportal.bath.ac.uk/en/persons/mirella-di-lorenzo
Dr Lucia Marucci (University of Bristol) http://www.bristol.ac.uk/engineering/people/lucia-marucci/overview.html
Dr Sandhya Moise, Department of Chemical Engineering (University of Bath) https://researchportal.bath.ac.uk/en/persons/sandhya-moise
Dr Despina Moschou, Department of Electronic & Electrical Engineering (University of Bath) https://researchportal.bath.ac.uk/en/persons/despina-moschou
The future of healthcare and advanced therapies will shift toward the delivery of more precise, personalised medicines, where patients are treated as individuals rather than receiving single ‘one-size-fits all’ treatment. The patient will be at the centre of the healthcare system with tailored solutions that adapt to individual patient needs. Nevertheless, unless novel manufacturing systems are developed, this scientific potential will not be realised. Current manufacturing systems are not suitable for patient-specific healthcare applications, as they are incapable of delivering therapies of sufficient precision and quality.
Supervised by an interdisciplinary team of academics, with expertise at the interface of Engineering, Material Science, Life Sciences with Stem Cell Biology, the PhD student carrying out the proposed research will develop an innovative platform for monitoring and controlling, in real time, mammalian cell (specifically T lymphocyte) proliferation and growth. This platform will allow the automation and refining of T cells culture conditions; thanks to an enhanced precision, robustness and control of the process, outcomes of this project could markedly advance the manufacture of cell-based therapies.
The project outputs can impact additional fields of research including, but not limited to, biosensing, drug delivery and other stem cell/immunotherapy bioprocesses. At its core, the innovation of this project lies at the interface between multiple disciplines that allows to combine, for the first time, novel biomanufacturing with electronic engineering and mathematics, to develop a Tcell manufacturing platform for robust treatment of chronic, life-threatening and debilitating conditions, such as cancer.
Applicants must have obtained, or be about to obtain, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science or technology.
How to apply:
Applications should be submitted on the University of Bath’s online application form for a PhD in Biosciences: https://samis.bath.ac.uk/urd/sits.urd/run/siw_ipp_lgn.login?process=siw_ipp_app&code1=RDUBB-DT01&code2=0004
Please ensure that you quote the supervisor’s name and project title in the ‘Your research interests’ section. You may apply for more than one project if you wish but you should submit a separate personal statement relevant to each one.
More information about applying for a PhD at Bath may be found on our website: https://www.bath.ac.uk/guides/how-to-apply-for-doctoral-study/