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Synthesis and Anti-Cancer Evaluation of New Heterocyclic Quinones


Faculty of Science, Engineering and Computing

About the Project

The group has published on small molecules with specificity towards hypoxic cells associated with solid tumours, reductase enzymes over-expressed in cancer, as well as, aziridines that induce hypersensitivity from Fanconi anaemia cells and those carrying mutations in the BRCA (Breast Cancer Susceptibility) genes.

Recent heterocyclic synthetic targets have included vasodilators and molecules that fragment into cytotoxic radicals using visible light, thus offering potential new photodynamic therapy treatments.

New projects will involve preparing synthetic targets with specificity towards certain molecular targets associated with cancer, as well as, studying cytotoxicity using enzymatic assays, induction of apoptosis, cell cycle arrest, and DNA-damage response. Training in all aspects will be provided, including aseptic and tissue culture techniques.

The PhD student will acquire excellent synthetic, analytical, and chemical problem solving skills, as well as, interdisciplinary skills associated with cancer research. Kingston University is equipped with the state-of-the-art analytical equipment, including 600 MHz NMR.


Funding Notes

There is no funding for this project: applications can only be accepted from self-funded candidates

References

M. Sweeney, F. Aldabbagh* et al., Bioorg. Med. Chem. 2016, 24, 3565.
M. Gurry, F. Aldabbagh* et al., Org. Lett., 2015, 17, 2856.
R. Coyle, F. Aldabbagh* et al., J. Org. Chem., 2014, 79, 5903.
V. Fagan, F. Aldabbagh* et al., Bioorg. Med. Chem. 2012, 20, 3223.

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