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Synthesis and Anti-Cancer Evaluation of New Heterocyclic Quinones


Project Description


The group has published on small molecules with specificity towards hypoxic cells associated with solid tumours, reductase enzymes over-expressed in cancer, as well as, aziridines that induce hypersensitivity from Fanconi anaemia cells and those carrying mutations in the BRCA (Breast Cancer Susceptibility) genes.

Recent heterocyclic synthetic targets have included vasodilators and molecules that fragment into cytotoxic radicals using visible light, thus offering potential new photodynamic therapy treatments.

New projects will involve preparing synthetic targets with specificity towards certain molecular targets associated with cancer, as well as, studying cytotoxicity using enzymatic assays, induction of apoptosis, cell cycle arrest, and DNA-damage response. Training in all aspects will be provided, including aseptic and tissue culture techniques.

The PhD student will acquire excellent synthetic, analytical, and chemical problem solving skills, as well as, interdisciplinary skills associated with cancer research. Kingston University is equipped with the state-of-the-art analytical equipment, including 600 MHz NMR.

Prof Aldabbagh is an experienced researcher, who joined Kingston University in September 2017, after more than 17 years at the National University of Ireland Galway. As principal investigator, he has supervised 23 PhD students to completion, and with his research students he has published more than 80 refereed articles in top-tier international journals.

Funding Notes

There is no funding for this project: applications can only be accepted from self-funded candidates

References

M. Sweeney, F. Aldabbagh* et al., Bioorg. Med. Chem. 2016, 24, 3565.
M. Gurry, F. Aldabbagh* et al., Org. Lett., 2015, 17, 2856.
R. Coyle, F. Aldabbagh* et al., J. Org. Chem., 2014, 79, 5903.
V. Fagan, F. Aldabbagh* et al., Bioorg. Med. Chem. 2012, 20, 3223.

How good is research at Kingston University in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 17.22

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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