Metal chelators have demonstrated their ability to combat the growth and survival of cancer cells. This is thought to be due to their ability to inhibit metalloenzymes or promote oxidative damage for example. To target cancer cells in preference to healthy cells, it is necessary to identify an uptake mechanism that is over expressed in the diseased ones. We have recently reported the first chelators that target LAT-1 and demonstrated their ability to kill melanoma cancer cells with high selectivity (1).
In this project, the PhD candidate will synthesise a new generation of our initial compounds aimed at improving their dose response by improving their ability to use LAT-1 as the uptake mechanism. The candidate will also screen these compounds and their controls against various cancerous and healthy cells lines to identify potential therapeutic application of the molecules.
The candidate is expected to be a synthetic organic chemist with a strong knowledge of biochemistry and willing to learn practical cellular biology.
Eligibility and How to Apply:
Please note eligibility requirement:
• Academic excellence of the proposed student i.e. 2:1 (or equivalent GPA from non-UK universities [preference for 1st class honours]); or a Masters (preference for Merit or above); or APEL evidence of substantial practitioner achievement.
• Appropriate IELTS score, if required.
• Applicants cannot apply for this funding if currently engaged in Doctoral study at Northumbria or elsewhere.
For further details of how to apply, entry requirements and the application form, see https://www.northumbria.ac.uk/research/postgraduate-research-degrees/how-to-apply/
Please note: Applications should include a covering letter that includes a short summary (500 words max.) of a relevant piece of research that you have previously completed and the reasons you consider yourself suited to the project. Applications that do not include the advert reference (e.g. SF20/…) will not be considered.
Deadline for applications: 1st July for October start, or 1st December for March start
Start Date: October or March
Northumbria University takes pride in, and values, the quality and diversity of our staff. We welcome applications from all members of the community. The University holds an Athena SWAN Bronze award in recognition of our commitment to improving employment practices for the advancement of gender equality.
Please direct enquiries to Dr David Tetard ([email protected]
Kyriakou S, Mitsiogianni M, Mantso T, Cheung W, Todryk S, Veuger S, Pappa A, Tetard D, Panayiotidis MI, Invest New Drugs. 2019 Jun 26. doi: 10.1007/s10637-019-00809-0.