About the Project
Recent research recognises the benefit of developing agents/compounds that possess anti-inflammatory and anti-VEGF activity as they may provide a more effective and novel strategy for treating AMD. Therefore, the project will involve the design and stereospecific synthesis of homoisoflavonoids and lignans for analysis as both anti-angiogenic and anti-inflammatory (specifically selective COX-II inhibitors) agents. The compounds will be analysed for COX-II inhibitory and other anti-inflammatory activity and cytotoxicity at Kingston University and for anti-angiogenic activity at the Glick Eye Institute in Indiana. The project will provide a diverse training experience for the student including both synthetic organic chemistry, tissue culture and the carrying out of key biological assays.
Schwikkard, S L; Alqahtani, A; Knirsch, W; Wetschnig, W, Opara, E. I, Jaksevicius, A, Langat, M K, Andriantiana, J and Mulholland, D A. (2017) Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species Journal of Natural Products, 80 (1), 30-37
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