Looking to list your PhD opportunities? Log in here.
This project is no longer listed on FindAPhD.com and may not be available.
Click here to search FindAPhD.com for PhD studentship opportunitiesAbout the Project
The PhD scholarship will be supported by the Australian Research Council (DECRA project) project entitled “Access to Biomimetic carbohydrate receptors using dynamic combinatorial chemistry”. A successful PhD student will be supervised by Dr Brendan Wilkinson (Monash University) and will work closely with international and local collaborators throughout the course of the project. The project will combine areas of organic synthesis, analytical chemistry and glycobiology for the development of biomimetic carbohydrate receptors, or “synthetic lectins”. The outcomes of this project will establish new structure-activity relationships with respect to the specificity and affinity of some poorly understood lectins, and help identify potential drug leads for the treatment of various cancers and microbial infection. The project will largely be conducted at the School of Chemistry, Monash University. The candidate will also be heavily involved in the biological screening and lectin array assays for synthesised receptors, which will be conducted at the Burnet Institute (Melbourne) and the Institute for Glycomics at Griffith University, respectively.
Interested candidates should directly contact Dr Brendan Wilkinson by e-mail: [Email Address Removed]
Funding Notes
References
1. Almkvist, J.; Karlsson, A. Glycoconjugate J. 2004, 19, 575-581
2. Hooper, L. V.; Gordon, J. I. Glycobiology 2001, 11, 1R-10R.
3. Barrow, H.; Rhodes, J. M. Int. J. Cancer 2011, 129, 1-8.
4. Thijssen, V. L.; Poirier, F.; Baum, L. G.; Griffioen, A. W. Blood 2008, 110, 2819-2827.
5. Sookcharoenpinyo, B.; Klein, E.; Ferrand, Y.; Walker, D. B.; Brotherhood, P. R.; Ke, C.; Crump, M. P.; Davis, A. P. Angew. Chem. Int. Ed. 2012, 51, 4586-4590.
6. Balzarini, J. Antivir. Chem. Chemother. 2007, 18, 1-11.