Proteoglycans including heparan sulfate proteoglycan are involved in mediating many interactions between cells and their environments. Our group has had success in using small-molecule mimetics of heparin-like saccharides in reducing cell motility via the HGF-Met pathway which could have important applications in cancer therapy (Raiber et al, Bioorg. Med. Chem. Lett., 2007, 17, 6321). This project will involve the design, synthesis and evaluation of further small-molecule sulfated compounds for use in cancer, wound healing and endothelial dysfunction. A high level of ability in synthetic organic chemistry will be needed and experience in biochemical testing would also be valuable.