Synthesis and testing of small-molecule heparin-mimics as potential anti-metastatic drugs

Dr J Wilkinson
Dr G Di Leva
Applications accepted all year round
Self-Funded PhD Students Only

School of Environment & Life Sciences, University of Salford

About This PhD Project

Project Description
Funding Notes
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Project Description

Proteoglycans including heparan sulfate proteoglycan are involved in mediating many interactions between cells and their environments. Our group has had success in using small-molecule mimetics of heparin-like saccharides in reducing cell motility via the HGF-Met pathway which could have important applications in cancer therapy (Raiber et al, Bioorg. Med. Chem. Lett., 2007, 17, 6321). This project will involve the design, synthesis and evaluation of further small-molecule sulfated compounds for use in cancer, wound healing and endothelial dysfunction. A high level of ability in synthetic organic chemistry will be needed and experience in biochemical testing would also be valuable.

Funding Notes

This PhD is self-funded

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Synthesis and testing of small-molecule heparin-mimics as potential anti-metastatic drugs

University of Salford

School of Environment & Life Sciences