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  Synthesis of Artificial blood


   Department of Chemistry

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  Dr L Twyman  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Inspired by Nature, we have developed a number of porphyrin containing biomimetic macromolecules. These have included a porphyrin cored polymer capable of reversibly binding oxygen. As such, these molecules have the potential to be applied as a plastic or artificial blood product. This work featured in two exhibitions at the Science museum in London and appeared in a number of newspapers articles, radio programmes and television documentaries around the world (including a documentary in Russia that received an estimated audience in excess of 80 million). Whilst this early prototype was successful, its clinical application was limited by its relatively small size and poor water solubility. This project aims to overcome these shortcomings, and will develop a larger water-based system that can be used in accident or emergency situations (battlefields or natural disaster areas). Specifically, the project will involve the synthesis of porphyrin a cored macromolecule that can bind and release oxygen. We also propose to encapsulate this molecule within a self-assembled micellar or vesicle system (synthesised from amphiphilic diblock polymers). As such, the self-assembled system will resemble and model a blood cell. Once constructed and assembled, studies to measure oxygen stability and reversible oxygen binding will then be undertaken.  

For more information, please contact Dr Twyman ([Email Address Removed]) and see Dr Lance J. Twyman | Chemistry | The University of Sheffield

Subject Area: synthetic chemistry, medicinal chemistry, supramolecular chemistry, drug delivery and macromolecules.

Click here to apply. Your application should be accompanied by a 1-page personal statement outlining your reasons for applying.

Funding

Applicants should have a scholarship or be self-funded. 

Requirements: At least a 2:1 honours degree or an MSc in Chemistry, or a related subject. 

Chemistry (6)

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 About the Project