or
Continue with FacebookLooking to list your PhD opportunities? Log in here.
About the Project
Despite mediating a plethora of vital biological processes in living organisms, peptides remain a challenging class of drug targets due to their poor cell penetration, proteolytic instability and unfavourable pharmacokinetics. Among the approaches employed to address these shortcomings, the incorporation of conformational constraints has the potential to enhance stability and, if the constraint is able to mimic a bioactive conformation, improve potency. We have devised a new asymmetric approach to lactam constrained amino acid building blocks bearing a range of polar and hydrophobic side chains. In this project, we will incorporate these constrained amino acids into bioactive short peptide sequences to develop new peptide mimics. We will also explore the late-stage ‘tagging’ of these fragments that will allow the incorporation of functional molecules such as fluorescent reporters.
https://www.sheffield.ac.uk/chemistry/people/academic/joseph-pa-harrity
Subject Area: Synthetic chemistry, asymmetric synthesis, catalysis, natural products synthesis.
Requirements: At least a 2:1 honours degree or an MSc with merit/distinction (or equivalent) in Chemistry.
Register your interest for this project
The university will respond to you directly. You will have a FindAPhD account to view your sent enquiries and receive email alerts with new PhD opportunities and guidance to help you choose the right programme.
It looks like you alredy have a FindAPhD Account
Log in to save time sending your enquiry and view previously sent enquiries
* required field
The information you submit to University of Sheffield will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.
How good is research at University of Sheffield in Chemistry?
Research output data provided by the Research Excellence Framework (REF)
Click here to see the results for all UK universities
Search suggestions
Based on your current searches we recommend the following search filters.
Check out our other PhDs in Sheffield, United Kingdom
Start a New search with our database of over 4,000 PhDs
PhD suggestions
Based on your current search criteria we thought you might be interested in these.
Synthesis of Metal-Organic Frameworks Using Rotaxane-based Ligands.
University of Birmingham
Design, synthesis and evaluation of novel antimalarials based on fendiline
University of Salford
Reactive extrusion based synthesis of thermoplastic cellulose derivatives
TalTech - Tallinn University of Technology