Synthesis of Peptidomimetics Based on Functionalizable Freidinger Lactams


   Department of Chemistry

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  Prof Joe Harrity  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Despite mediating a plethora of vital biological processes in living organisms, peptides remain a challenging class of drug targets due to their poor cell penetration, proteolytic instability and unfavourable pharmacokinetics. Among the approaches employed to address these shortcomings, the incorporation of conformational constraints has the potential to enhance stability and, if the constraint is able to mimic a bioactive conformation, improve potency. We have devised a new asymmetric approach to lactam constrained amino acid building blocks bearing a range of polar and hydrophobic side chains. In this project, we will incorporate these constrained amino acids into bioactive short peptide sequences to develop new peptide mimics. We will also explore the late-stage ‘tagging’ of these fragments that will allow the incorporation of functional molecules such as fluorescent reporters.

[Email Address Removed]

https://www.sheffield.ac.uk/chemistry/people/academic/joseph-pa-harrity

Subject Area: Synthetic chemistry, asymmetric synthesis, catalysis, natural products synthesis.

Requirements: At least a 2:1 honours degree or an MSc with merit/distinction (or equivalent) in Chemistry. 

Chemistry (6)

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 About the Project