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Synthetic Biology of the peroxisome


Project Description

Compartmentalisation is a fundamental feature of eukaryotic cells and increases efficiency and complexity by segregating incompatible reactions and concentrating intermediates. Our previous work has utlised understanding of a key protein-protein interaction between a targeting signal and receptor to produce an ‘orthogonal pair;’ which can be used to deliver user specified protein components to the peroxisome. Use of a cell compartment for synthesis of high value biochemical or storage of high value proteins can potentially have deleterious effects due to negative impacts on essential endogenous processes and reactions, therefore this project seeks to build on our previous work to try to produce a completely orthogonal peroxisome that can co-exist with the native peroxisome in S.cerevisiae and thereby circumvent this problem. The project will combine cell biology and metabolic engineering type approaches to test our understanding of the rules for making and programming the metabolism of an organelle.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2020:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference and research funding

Requirements:
At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.

EU candidates require 3 years of UK residency to receive full studentship

Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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References

Cross LL. Paudyal R. Kamisugi Y. Berry A .Cuming AC. Baker A. Warriner SL (2017) Towards designer organelles by subverting the peroxisomal import pathway. Nature Communications 8:454 (http://rdcu.be/vCkL )

DELOACHE, W. C., RUSS, Z. N. & DUEBER, J. E. 2016. Towards repurposing the yeast peroxisome for compartmentalizing heterologous metabolic pathways. Nature Communications, 7, 11152.

ZHOU, Y. J., BUIJS, N. A., ZHU, Z., GÓMEZ, D. O., BOONSOMBUTI, A., SIEWERS, V. & NIELSEN, J. 2016. Harnessing Yeast Peroxisomes for Biosynthesis of Fatty-Acid-Derived Biofuels and Chemicals with Relieved Side-Pathway Competition. Journal of the American Chemical Society, 138, 15368.

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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