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Synthetic Biology Pipeline for Discovery and Diversification of Novel, Bioactive Natural Products from Marine Cyanobacteria

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  • Full or part time
    Dr R Goss
    Dr Douglas McKenzie
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

An IBIOIC/MASTS funded PhD studentship is available for an exceptional candidate with a strong background in micro/molecular biology. A background in natural product chemistry and organic compound analysis would also be beneficial. Candidates must have, or be expected to obtain, a degree in Chemistry, Biochemistry, Microbiology or an appropriate related subject.

Summary: The quest for new antibiotics, especially those with activity against Gram negative and recalcitrant bacteria, is urgent. Over 13 million lives world-wide are currently claimed each year due to infectious diseases. Over the last decade this figure has doubled due to the emergence of multi-drug resistant strains. Conversely very few new antibiotics have been introduced to the market in the last 40 years, with this limited number falling into only four new structural classes.1, 2 The Global cost of antimicrobial resistance to GDP is calculated as between $2.1 trillion-$124.5 trillion dollars. (RAND report) We propose to a marine microbial pipeline for the discovery of novel antibiotics with which to address AMR.

Funding Notes

Funded PhD studentship is available for an exceptional candidate with a strong background in micro/molecular biology. A background in natural product chemistry and organic compound analysis would also be beneficial. Candidates must have, or be expected to obtain, a degree in Chemistry, Biochemistry, Microbiology or an appropriate related subject. Upper second-class degree in Chemistry or related area.

Please note this PhD position will be part of the IBioIC CTP, please check this website for further details on the programme (http://www.ibioic-ctp.com/)

References

[1] G. D. Wright, ACS Infect. Dis. 2015, 1, 80
[2] J.S. Zarins-Tutt, R.J.M.Goss et al. Nat. Prod.Rep. 2016, 33, 54.
[3] J.S. Zarins-Tutt, R.J.M.Goss Emily Abraham and Rebecca J. M. Goss*, Prog. Mol. Biol.,Blue Biotechnology, 2017, 55, 159-186.

How good is research at University of St Andrews in Chemistry?
(joint submission with University of Edinburgh)

FTE Category A staff submitted: 37.30

Research output data provided by the Research Excellence Framework (REF)

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