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Synthetic biology toward innovative virus-like particles

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Virus-like particles (VLP) are self-assembled viral proteins that do not contain genetic material and are non-infectious. VLPs have been successfully developed into particulate vaccines for prevention of viral infections such as human papilloma virus or Hepatitis B. This project aims to link the assembly of VLPs with biopolyester synthesis inside engineered Escherichia coli. The VLP-biopolyester hybrid material will be characterised and its utility towards medical uses such as in drug delivery or as vaccine will be tested.

Funding Notes

About the Scholarship

The 2019 Griffith University Postgraduate Research Scholarship has an annual stipend of $27,596 (indexed) for a period of up to three years of full-time study. Please see the GUPRS Conditions of Award for more information: View Website

A successful International applicant will also be awarded a Griffith University International Postgraduate Research Scholarship to cover tuition fees for up to three years. Please see the GUIPRS Conditions of Award for more information: View Website

References

1. Rehm, B. H. A., Bioengineering towards self-assembly of particulate vaccines. Current Opinion in Biotechnology 2017, 48, 42-53.

2. Sainsbury, F. et al., Engineering Recombinant Virus-like Nanoparticles from Plants for Cellular Delivery. ACS Nano 2017, 11 (4), 3476-3484.

3. Dashti, N. H.; Abidin, R. S.; Sainsbury, F., Programmable In Vitro Coencapsidation of Guest Proteins for Intracellular Delivery by Virus-like Particles. ACS Nano 2018, 12 (5), 4615-4623.

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