Synthetic Biology at Imperial College London on FindAPhD.com

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Dr K Sarkisyan, Prof A Fisher No more applications being accepted Funded PhD Project (UK Students Only)

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London United Kingdom Applied Mathematics Biochemistry Bioinformatics Biophysics Biotechnology Data Analysis Evolution Genetics Molecular Biology Software Engineering

MRC London Institute of Medical Sciences (LMS), Imperial College London

About the Project

We are a synthetic biology lab at the MRC London Institute of Medical Sciences & Imperial College London. We love high-throughput assays, protein engineering, light-based biotechnologies and automation, and work in several research directions, both basic and applied. We are looking for a colleague with a genuine interest in understanding and engineering biology and extensive wet lab experience.

The proposed project is a collaboration with Amanda Fisher’s lab and London Biofoundry. We will use modern approaches to protein engineering to create multicellular organisms with self-sustained bioluminescence, with the ultimate goal of being able to visualize almost any physiological process in non-invasive longitudinal imaging studies.

Previous experience with various DNA assembly techniques or animal experimentation is desirable but not essential, as well as coding skills.

For more information, please visit our websites: https://www.designing.bio/ and https://lms.mrc.ac.uk/research-group/epigenetic-memory/

To apply, please visit the link below;

https://lms.mrc.ac.uk/study-here/phd-studentships/lms-3-5yr-studentships/

Funding Notes

The funding for this studentship includes full (Home rate) tuition fees for 3.5 years as well as a generous stipend amounting to £21,000pa paid directly to the student for the same duration.
Please note that we are only able to accept applications from Home Fee rate students, which includes students with settled status or pre-settled status covering the duration of the whole studentship (until June 2026).

References

1. Gonzalez Somermeyer L, Fleiss A ... Sarkisyan KS*#, Kondrashov FA*#. Heterogeneity of the GFP fitness landscape and data-driven protein design. Biorxiv, 2022. https://doi.org/10.1101/2021.12.08.471728
2. Mitiouchkina T*, Mishin AS*, Gonzalez Somermeyer L*, Markina NM*,... Yampolsky IV, Sarkisyan KS. Plants with genetically encoded autoluminescence. Nature Biotechnology, 2020. https://www.nature.com/articles/s41587-020-0500-9
3. Ding SS, Romenskyy M, Sarkisyan KS, Brown AEX (2020). Measuring C. elegans spatial foraging and food intake using bioluminescent bacteria. Genetics, 2020. https://doi.org/10.1534/genetics.119.302804
4. Fleiss A and Sarkisyan KS. A brief review of bioluminescent systems (2019). Current Genetics, 2019. doi.org/10.1007/s00294-019-00951-5
5. Kotlobay A*, Sarkisyan KS* et al. A genetically encodable bioluminescent system from fungi. PNAS, 2018. doi.org/10.1038/nature17995
6. Sarkisyan KS*, Bolotin DA* et al., Local fitness landscape of the green fluorescent protein. Nature, 2016. doi.org/10.1038/nature17995