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Synthetic Medicinal Carbohydrate Chemistry PhD in the area of Glycomimetics.

  • Full or part time
  • Application Deadline
    Monday, April 01, 2019
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

The successful candidate will work on a project concerned with the design and synthesis of glycomimetics. Specifically they will synthesize complex target molecules designed against various targets such as galectin-8 and siglec-8 involved in asthma and some forms of inflammation/cancer. The project will involve producing desired compounds and purifying them to a high level to be distributed to international collaborators involved in the project. The PhD student will also be expected to have an interest in carrying out relevant bioassays, including biophysical measurements.

Duties:
• Design and synthesis of mimetics of sialyl lactose for relevant biological targets involved in cancer and inflammation such as galectin-8 and siglec-8
• Candidates should have excellent communication and organizational skills; be highly motivated and passionate about developing new products; and have strong documentation, oral and interpersonal skills.
• PhD students normally enter the School of Chemistry structured programme. Students will be required to take relevant courses, including in research ethics, health and safety etc.
• Applicants should be aware that PhD students contribute to the teaching of undergraduates in the School of Chemistry at NUI Galway. This will include supervision of undergraduate research students and MSc students in the supervisor’s laboratory.
• The successful candidate will also make a contribution to the running of the supervisor’s laboratory and outreach/education and public engagement.

Qualifications/Skills required:

• Normally an MSc completed in the area of synthetic organic chemistry before commencing. A BSc graduate of Chemistry may be recruited if they have demonstrated excellent performance and who have obtained experience in using relevant synthetic and relevant analytical techniques. They should have an introductory knowledge of techniques used for structure determination (e.g. NMR spectroscopy).
• The successful candidate will have an interest in carbohydrate chemistry, medicinal chemistry and synthesis as well as being willing to carry out bio(physical)assays with new compounds.
• It will be an advantage to have an interest in computational methods and 3D structure as applied in medicinal chemistry.
• There may be the opportunity to carry out a short placement at a leading international laboratory during the course of the study in the area of biophysical chemistry.
• Strong communication and interpersonal skills, including good writing skills, are required as is the ability to work well within a team

Scholarship: € 18,500 per annum with an additional contribution of €5,500 towards fees/levies etc as per SFI awards. There are also some funds available for attending a relevant conference to present results from the research work.

Start date: As soon as possible thereafter.

To Apply:

Preliminary applications can be made by email and must be sent to and must contain ‘Glycomimetic PhD studentship’ in the subject line.

In your application please include

1. A covering letter which gives a detailed personal statement including your motivation for applying for this particular studentship
2. A pdf copy of an example of your own independent written research work (e.g. BSc thesis, MSc thesis) in the area of chemistry.
3. A full CV including the contact details of two referees. Include the list of any awards and evidence of excellent academic performance to date. Please detail any experience in the area of synthetic chemistry.

Funding Notes

Funding is provided by Science Foundation Ireland and the European Regional Development Fund.

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