[Synthetic Organic ElectroSynthesis] - Electrochemical fluorination of Pharmaceutical Molecules with Placement at AstraZeneca


   Department of Pharmaceutical, Chemical and Environmental Sciences

   Friday, September 30, 2022  Funded PhD Project (Students Worldwide)

About the Project

About the Projects

Organofluorine compounds display unique physical, chemical and biological properties compared to their hydrogenated analogues. Therefore, it is not surprising to find numerous fluorinated molecules among the top best-selling drugs. However, the installation of a fluorine atom remains far from trivial. Hence, this project proposes developing a new practical, cheap, scalable and green method for the electrofluorination of aliphatic and aromatic compounds.

We are now looking for highly motivated PhD students to join our team and further explore the synthetic potential of organic electrosynthesis.

The candidate:

The projects would be suitable for a student with a strong background in synthetic chemistry and an interest in electrochemistry.

The Student will be supervised by Dr Kevin Lam (http://www.lamresearchgroup.com) and join a group of young, international and dynamic researchers!

The Laboratory:

The Lam Group is housed within a newly refurbished laboratory and is very well equipped with more than 14 Electrasyns 2.0, an electrochemical flow system, a glovebox, a solvent purification system, several automatic chromatography columns, its own GC-MS and HPLC-MS, etc.

The university will also provide the student with routine access to 4 NMR spectrometers, several UPLC-MS, a high-resolution mass spectrometer, MALDI-TOF, etc.


Funding Notes

The grant will cover the Home (UK and Ireland) tuition fees and offer a stipend in line with UKRI. Non-UK/IE applicants are welcome, but funding will cover only the tuition fees, and the international applicant will have to secure additional funding to cover their living expenses.

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