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Synthetic Organic Photochemistry: Synthesis and Applications of [3]Prismanes


   Department of Chemistry

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  Dr Susannah Coote, Dr Alex Cresswell  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

A fully funded 4-year PhD CASE studentship in the area of organic/medicinal chemistry is available at the University of Bath in collaboration with GSK in Stevenage (subject to contract). The position will be supervised by Dr Susannah Coote (moving to Bath in January 2023) and Dr Alex Cresswell.

Dr Susannah Coote’s research group focuses on the development of creative organic chemistry for the construction of “difficult-to-make” molecules (with particular emphasis on photochemical reactions), and collaborates with other research teams to develop applications of the new molecules in a variety of applications, including as novel building blocks and fragments for drug discovery. More information on the group can be found at: www.susannahcoote.wordpress.com.

Anticipated Start Date:

16 January 2023. There may be flexibility for a later start date - please discuss with the lead supervisor prior to applying.

Project Overview:

The project will focus on the synthesis of [3]prismane derivatives, as well as their applications as synthetic building blocks and in medicinal chemistry. [3]Prismanes are interesting three-dimensional structures that have so far received no attention in the context of medicinal chemistry – not because these motifs lack potential, but because they are currently not easy to prepare. The project will build on the synthetic methodology developed previously within the group (Org. Lett. 2019, 22, 9232) to realise a new synthetic route to a range of [3]prismane derivatives, then investigate their synthetic potential in further transformations. In collaboration with GSK, the stability and applications of the new molecules in medicinal chemistry will also be investigated.  

During the course of this project, you will be trained in core practical techniques in synthetic organic chemistry, including synthetic photochemistry and flow chemistry, and will have the opportunity to further your knowledge through regular group meetings and seminars. You will gain extensive experience in characterisation techniques (e.g. NMR/IR spectroscopy, mass spectrometry, X-ray crystallography), and in particular, “no-D” NMR spectroscopy will be used extensively for reaction monitoring and stability studies.

Project keywords: organic chemistry, medicinal chemistry, photochemistry, synthesis.

CASE Partner (subject to contract):

GlaxoSmithKline (Stevenage). The successful candidate will be assigned an industrial supervisor (based at GSK), who will provide input to the project, and there is an opportunity for a 3-month placement at GSK Stevenage, gaining valuable industrial experience.

Candidate Requirements:

Applicants will hold, or expect to receive, a 1st class or 2:1 UK Masters-level degree (or equivalent) in Chemistry or a closely related discipline, and possess theoretical and practical skills commensurate with a chemistry-based undergraduate degree programme. The successful candidate will demonstrate a strong interest and relevant experience in organic chemistry, as well as an interest in medicinal chemistry. In addition, enthusiasm to work in a laboratory environment, willingness to learn, a collaborative attitude, and good written and oral communication skills will be required. 

Non-UK applicants must meet our English language entry requirement.

Enquiries and Applications:

Informal enquiries are welcomed and should be directed to Dr Susannah Coote on email address: [Email Address Removed].

Formal applications should be made via the University of Bath’s online application form for a PhD in Chemistry.

More information about applying for a PhD at Bath may be found on our website.

NOTE: Applications may close earlier than the advertised deadline if a suitable candidate is found. We recommend that you contact Dr Coote prior to applying and then submit your formal application as early as possible.

Equality, Diversity and Inclusion:

We value a diverse research environment and aim to be an inclusive university, where difference is celebrated and respected. We welcome and encourage applications from under-represented groups.

If you have circumstances that you feel we should be aware of that have affected your educational attainment, then please feel free to tell us about it in your application form. The best way to do this is a short paragraph at the end of your personal statement.


Funding Notes

The successful candidate will receive a 4-year EPSRC DTP PhD studentship covering Home tuition fees and a stipend at the UKRI rate (£17,668 per annum in 2022/23). The project will be carried out in partnership with GSK plc who will provide a stipend enhancement of £3,000 per annum and access to a research and training support budget of up to £5,000 per annum, subject to contractual agreement. Unfortunately, we cannot consider international candidates for this position.

References

https://pubs.acs.org/doi/10.1021/acs.orglett.9b03613.

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