PhD LIVE Study Fair

Oxford | Edinburgh | Sheffield

Coventry University Featured PhD Programmes
Sheffield Hallam University Featured PhD Programmes
Engineering and Physical Sciences Research Council Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
University of Reading Featured PhD Programmes

Systematic cell reprogramming –transdifferentiation– cell fate and evolution using computational approaches.

  • Full or part time
  • Application Deadline
    Tuesday, December 03, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The field of regenerative medicine was stunned in 2007 by the possibility of creating stem cells from adult human cells (1). Since then it has been shown that it is also possible to trans-differentiate from one mature human cell type to another. The process however is still poorly understood, and as a result, only a handful of different human cell types have successfully been created in the decade following the 2007 discovery (by Yamanaka).

We apply computational approaches to the predominantly experimental field of cell differentiation that bring a systematic and data-driven guide for directing research in the field (2). We combine theory of transcriptional regulation and cell networks with big data from high-throughput experiments relating to gene expression and molecular interaction. As well as expanding the repertoire of possible human cell conversions and pushing the boundaries of cellular manipulation, the PhD project will aim to deepen the understanding of cell fate and evolution (3).

The project would suit highly motivated individuals coming from a range of scientific disciplines, but an aptitude for theoretical and technical thinking will be essential for developing computational skills required to carry out the research.

Funding Notes

Please see the LMB PhD website for further details: View Website

References

1) Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 5, 861-872.

2) Rackham, O.J.L., Firas, J., Fang, H.,Oates, M.E., Holmes, M.L., Knaupp, A.S., The FANTOM Consortium, Suzuki, H.,Nefzger, C.M., Daub, C.O., Shin, J.W., Petretto, E.P., Forrest, A.R.R., Hayashizaki, Y., Polo, J.M. and Gough, J. (2016) A predictive computational framework for direct reprogramming between human cell types. Nature Genetics, 331-335.

3) Sardar, A.J., Oates, M.E., Fang, H., Forrest, A.R.R., Kawaji, H., The FANTOM consortium, Gough, J. and Rackham, O. (2014) The Evolution of Human Cells in Terms of Protein Innovation. Mol. biol. evol., 31(6), 1364-74.

Related Subjects

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.