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Tackling antimicrobial resistance through non-invasive diagnostics

Project Description

As our understanding of treatment protocols becomes more sophisticated, for example, in personalising medicine to match a patient’s response to a drug or in prescribing appropriate drugs for an evolving disease, the requirement to monitor continuously a patient becomes essential. One such approach for continuous monitoring that will be developed in this PhD project is the use of non-invasive sampling of transdermal fluid – that is fluid that sits just below the outer layer of the skin.

The focus of this PhD project will be on the development of fluidic sample handling technologies and their integrated into non-invasive transdermal fluid patches. The specific application focus will be on tackling antimicrobial resistance (AMR) through non-invasive diagnostics where the correct prescribing of antibiotics to a patient ensures the long-term effectiveness of antibiotics. Consequently, the ability of the healthcare profession to treat a range of bacterial infections will not be lost due to poor prescribing practices and subsequent development of drug-resistant strains.

This is 4 year fully-funded PhD studentship funded jointly by the Medical Research Foundation National PhD Training Programme in Antimicrobial Resistance (AMR), led from the University of Bristol and the University of Leeds. The ideal candidate will have a background in engineering or physics and be enthusiastic about developing new skills, for example in materials, fluid mechanics and manufacturing methods to advance the state-of-the-art in this area. The ideal candidate should have the ability to think across traditional boundaries, to draw on a range of engineering tools and have excellent communication skills in order to work with supervisory staff (and the wider project team) with a range of academic backgrounds.

Funding Notes

A fully funded studentship for 4-years consists of academic fees (£4,327 in Session 2019/20), together with a maintenance grant at the MRC stipend ‘plus’ rate (£17,000 in Session 2019/20), plus research costs and travel allowance. UK applicants will be eligible for a full award paying tuition fees and maintenance. European Union applicants will be eligible for an award paying tuition fees only, except in exceptional circumstances, or where residency has been established for more than 3 years prior to the start of the course.

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