About the Project
Training/techniques to be provided:
The student will receive training in the growth, differentiation and phenotypic characterisation of induced pluripotent stem cells to endothelial cells, pericytes, astrocytes, microglia and neurons, as well as in measurements of cell proliferation and viability, expression of appropriate markers, functional assays, including transendothelial resistance measurement. Training in the use of confocal immunofluorescence microscopy and other advanced microscopy techniques will be provided through the Faculty’s Core Facility. The student will receive full training in generation of hydrogels and in state of the art 3D Bioprinting for the production of tissue models with discrete and/or continuous gradients. He/she will also have access to our core facilities for mechanical, morphological and chemical characterization of materials and scaffolds.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (B.Sc. or equivalent) in a related area / subject (e.g. biochemistry, cell biology, neuroscience, biomaterials) and preferably a master degree in a related area. Candidates with experience in mammalian cell biology or use of biomaterials are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Jarosz-Griffiths, H.H., Corbett, N.J., Rowland, H.A., Fisher, K., Jones, A.C., Baron, J., Howell, G.J., Cowley, S.A., Chintawar, S., Cader, M.Z., Kellett, K.A.B. & Hooper, N.M. (2019) Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers. J. Biol. Chem. 294, 7085-7097.
Potjewyd, G., Moxon, S., Wang, T., Domingos, M., and Hooper, N. M. (2018) Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective. Trends Biotechnol 36, 457-472
Rowland, H. A., Hooper, N.M. & Kellett, K.A.B. (2018) Modelling sporadic Alzheimer’s disease using pluripotent stem cells. Neurochemical Res. 43, 2179-2198.
Raphael, B., Khalil, T., Workman, V.L., Smith, A., Brown, C.P., Streuli, C., Saiani, A. & Domingos, M. (2017) 3D cell bioprinting of self-assembling peptide-based hydrogels, Materials Letters, 190, 103-106
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.