Proteins undergo post-translational modifications (PTMs) that have evolved in all forms of life as a mechanism for rapidly adapting protein function in response to many different kinds of stimuli. PTMs are known to be involved with cell signalling, enabling protein-protein interactions, protein turnover, and in the context of plants, are intrinsically involved in key traits, such as response to stresses (drought, flooding, pathogens).
In this project, you will be working on an emerging protein modification system called SUMO. You will be trained in the latest omics technologies such as proteomics, single cell transcriptomics and light sheet bioimaging to understand how environmental signals enable the cellular machinery to add or remove SUMO from target proteins, and thus rapidly alter their function. You will also be trained in computational biology to analyse these data types. You will be trained in coding, data visualisation and machine learning, with a view to the discovery of the functional consequences of SUMOylation that are intrinsically associated with desirable traits in plants. You will be embedded within a highly active and collaborative research environment, with potential for involvement with, and travel to, major international research programmes that aims to understand adaptive responses mediated by post-translational modification.
Informal enquiries may be made to [Email Address Removed]
HOW TO APPLY
Applications should be made by emailing [Email Address Removed] with a CV and a covering letter, including whatever additional information you feel is pertinent to your application; you may wish to indicate, for example, why you are particularly interested in the selected project/s and at the selected University. Applications not meeting these criteria will be rejected. We will also require electronic copies of your degree certificates and transcripts.
In addition to the CV and covering letter, please email a completed copy of the NLD BBSRC DTP Studentship Application Details Form (Word document) to [Email Address Removed], noting the additional details that are required for your application which are listed in this form. A blank copy of this form can be found at: https://www.nld-dtp.org.uk/how-apply.
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