Talent4BBI PhD7 - Enzyme development for sustainable production of pharmaceutical ingredients.

Enzyme development for sustainable production of pharmaceutical ingredients. The University of Groningen (UG) group will identify and redesign amide-bond formation enzymes using in-house developed computational design protocols. Designs are produced by recombinant methods and tested in collaboration with FK/EnzyPep. The project should lead to a biocatalyst that is applicable in green synthetic routes for peptide API production from renewables, including the renewable production of the biocatalyst itself.

Using tools such as molecular modelling, computational design, docking and molecular dynamics simulations the most promising template enzymes will be optimized towards better production of peptide API. Protein crystallography will be used to solve structures of the selected templates and tailored variants. Key performance parameters will be quantified, incl. enzyme stability, resistance to cosolvents, and kinetic properties. The best enzymes will be shared for application tests.

The ESR will perform experimental and computational work at the University of Groningen. In addition, the ESR will spend time at EnzyPep, location in Geleen (NL), to work on enzyme fermentation (6 mo) and eventually prepare the process for scale-up in the pilot facilities.

This is a Marie Curie COFUND Position based in Netherlands with Industry (Fresenius Kabi I&D Center EnzyPep BV) and Academic Partner (Groningen)

Applications will only be accepted via the application portal that can be accessed on the link below.

Further Details on how to apply including eligibility are included in the application guideline document.

https://biorbic.com/talent4bbi/#recruitment-call-information

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