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Targeting bacterial membrane proteins for new antimicrobial strategies


   Warwick Medical School

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  Prof D Roper  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

PhD in Interdisciplinary Biomedical Research

Fully funded studentship available for entry in September 2022

This industrial Collaborative Award in Science and Engineering (iCASE) studentship is offered by Warwick’s MRC Funded Doctoral Training Partnership (DTP). The training program involves an exciting one-year MSc in Interdisciplinary Biomedical Research and then a three-year PhD project, co-supervised by experts from both academia and industry. Students join a dynamic DTP community, which includes advanced workshops, transferable skills training, careers support and cohort learning events and conferences with ~50 other students.

We are constantly working to create a supportive and inclusive environment to help students achieve their best potential, through promoting equality and challenging discrimination. We want our students to feel heard and valued for their hard work. We welcome and encourage applications from minoritised groups that are under-represented in academia.

Please note that this project is available to UK nationals only. 

Project summary:

Bacterial antibiotic resistance is a global health challenge, recognised as an area of concern in public health and biodefence. New drug development is a lengthy and costly process, but investment in new antibiotic development by large pharma is in decline. The void in this sector is being filled by academic and SME engagement to provides novel leads to new safe and effective antibiotics. In this joint iCASE project with Defence Science and Technology Laboratory (Dstl) we will investigate a section of essential membrane protein complexes in specific organisms of interest. The project aims to focus on a selection of these essential genes and assess their suitability for further study as antibacterial drug targets. We will take an interdisciplinary approach using genetics, biochemistry, novel membrane proteins, extraction strategies and drug discovery tools to study these targets and investigate novel chemotherapeutic opportunities.

Industry Partner: Defence Science & Technology Laboratory

PROGRAMME CONTENT

MSc (Year One)

Students undertake a series of taught modules, including Frontier Techniques in Biomedical Research, Physical Biology of the Cell, Microscopy and Imaging, Mathematical Modelling, Mass Spectrometry, and two laboratory-based research projects. 

PhD (Years Two, Three and Four)

Student support

Students receive outstanding mentoring, careers and pastoral support throughout the programme.

ENTRY REQUIREMENTS, FUNDING AND HOW TO APPLY

Entry requirements

Candidates must have:

  • An excellent undergraduate degree (2:i or above) in the biological, physical or computational sciences.
  • Advanced skills in mathematics (A-Level or international equivalent).  

The project would suit a highly motivated undergraduate with existing laboratory skills experience and a keen interest in addressing antimicrobial resistance in a collaborative project with industry partners.

How to apply

If you are interested in joining our DTP community, please apply here by 15 February 2022. Interviews will take place in the week commencing 4 April 2022.

For further information please see warwick.ac.uk/mrcdtp 


Funding Notes

Studentships cover full fees, consumables, conference attendance and an annual stipend (£18,340 in 2022/23*). Students can also apply for additional funding from the DTP for advanced training workshops, international or industry placements, internships and career transition support.
* Estimated stipend amount; exact figure to be confirmed
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