The project will be focused on the knowledge-based design of active compounds targeting several proteins or protein-protein interactions, which are implicated in the development of hematological malignancies (acute lymphoblastic leukemia and mixed-lineage leukemia). The compounds will be developed using the fragment-based approach. The work on this project provides the opportunity to acquire expertise in protein biochemistry, biophysics and structural biology (NMR spectroscopy and X-ray crystallography), as well as to get an insight into the rational drug design process through close collaboration with the medicinal and computational chemists.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications
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