Targeting inflammation for early treatment of chronic kidney disease-associated cardiomyopathy


   Institute of Cardiovascular Sciences

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  Dr Christopher O'Shea, Dr D Pavlovic  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Other supervisors: Prof Andre Ng (University of Leicester), Prof Claudio Mauro and Dr Katja Gehmlich (University of Birmingham)

Informal enquiries should be directed to the project supervisor Dr Christopher O'Shea - [Email Address Removed]

Person Specification:

Applicants should have a strong background in medical or biological sciences. They should have a commitment to cardiovascular research and hold or realistically expect to obtain at least an Upper Second Class Honours Degree in a relevant subject.

Project Details:

Chronic kidney disease (CKD) is a major and growing health concern. By 2040 it is likely to be the 5th biggest killer worldwide. CKD often results in cardiac dysfunction, and it is cardiac complications that most commonly lead to mortality in CKD patients. What is unique about CKD-induced cardiac disease, and therefore how best to treat it, is not fully understood. Current research focuses on end stage CKD, but by then it is often too late to reverse any cardiac disease. In this studentship, we will model early CKD, how this detrimentally effects the heart, and whether we can treat CKD-associated cardiac disease. CKD causes systemic inflammation, and we believe this plays a key role. We will therefore fully profile the inflammatory state of early CKD. We will then use cutting-edge techniques to study the structure of the heart, and map electrical behaviour across the entire organ. We will then translate our findings towards the clinic using more human models, and human cardiac cells differentiated from induced pluripotent stem cells. This research will offer insights into inflammation's role in early CKD-associated cardiac disease and provide evidence for novel preventive treatments for patients.

How to apply:

Click on the visit institutional website button which will direct you to the MRC AIM DTP website where you will find full information together with the application forms. Please ensure your application is submitted by the deadline, midday (GMT) Friday 12 January 2024, as late applications will not be considered.

Biological Sciences (4) Engineering (12) Medicine (26) Sport & Exercise Science (33)

Funding Notes

This is a fully funded studentship provided by the Medical Research Council.
If you are successful, you will receive a stipend (currently £18,622 per year for 2023/24) and a tuition fee waiver for 4 years.
Successful candidates will also receive an allowance for a laptop, a travel and conference allowance and an allowance for laboratory/PhD running costs.

References

Law, J. P., Pickup, L., Pavlovic, D., Townend, J. N. & Ferro, C. J. Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations. J. Hum. Hypertens. 37, 1–19 (2023).
O’Shea, C. et al. ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology. Sci. Rep. 9, 1–13 (2019).
Rapa, S. F., Di Iorio, B. R., Campiglia, P., Heidland, A. & Marzocco, S. Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int. J. Mol. Sci. 21, 263 (2019).
Harada, M. & Nattel, S. Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology. Card. Electrophysiol. Clin. 13, 25–35 (2021).

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