Other supervisors: Prof Andre Ng (University of Leicester), Prof Claudio Mauro and Dr Katja Gehmlich (University of Birmingham)
Informal enquiries should be directed to the project supervisor Dr Christopher O'Shea - [Email Address Removed]
Applicants should have a strong background in medical or biological sciences. They should have a commitment to cardiovascular research and hold or realistically expect to obtain at least an Upper Second Class Honours Degree in a relevant subject.
Chronic kidney disease (CKD) is a major and growing health concern. By 2040 it is likely to be the 5th biggest killer worldwide. CKD often results in cardiac dysfunction, and it is cardiac complications that most commonly lead to mortality in CKD patients. What is unique about CKD-induced cardiac disease, and therefore how best to treat it, is not fully understood. Current research focuses on end stage CKD, but by then it is often too late to reverse any cardiac disease. In this studentship, we will model early CKD, how this detrimentally effects the heart, and whether we can treat CKD-associated cardiac disease. CKD causes systemic inflammation, and we believe this plays a key role. We will therefore fully profile the inflammatory state of early CKD. We will then use cutting-edge techniques to study the structure of the heart, and map electrical behaviour across the entire organ. We will then translate our findings towards the clinic using more human models, and human cardiac cells differentiated from induced pluripotent stem cells. This research will offer insights into inflammation's role in early CKD-associated cardiac disease and provide evidence for novel preventive treatments for patients.
How to apply:
Click on the visit institutional website button which will direct you to the MRC AIM DTP website where you will find full information together with the application forms. Please ensure your application is submitted by the deadline, midday (GMT) Friday 12 January 2024, as late applications will not be considered.