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Targeting Intracellular amyloid-beta (Aβ) peptide in a human induced pluripotent stem cell derived cortical organoid model

Project Description

A fully funded 3-year PhD studentship is available to develop methods to degrade Aβ in human induced pluripotent stem cell derived cortical organoid model.

A large percentage of our ageing population is affected by late onset chronic diseases affecting the nervous system, known as neurodegenerative diseases. One of these- Alzheimer’s disease (AD), is the most common cause of progressive dementia in the elderly population. Despite the scale of incidence of AD there remains no effective treatment to delay or prevent neurodegeneration in patients. Thus, there is a pressing need for scientific research into dementia and new therapeutic approaches to become a priority - not only to minimise suffering among patients but also to combat the increasing financial burden on societies across the World.

A small protein fragment termed Aβ accumulates as amyloid plaques in the brain of patients with AD. It is toxic, causes brain cells to die, believed to be the primary cause of AD. Therefore, developing strategies to reduce the amount of Aβ in the brain constitutes a rational therapeutic approach.

The student will develop approaches to degrade Aβ (both the monomeric and oligomeric forms) in a 3-D brain organoid model derived from stem cells reprogrammed from cells of AD patients. The student will gain experience in protein biochemistry, cell biology and stem cell derived ‘Disease in a Dish models.’

Applications are welcome from applicants in the UK/ EU who have or expect to obtain a First Class or high upper second class degree in Biochemistry or Molecular Cell Biology with an strong interest/experience in neurobiology. Placement experience is desirable.

How to apply:

Informal enquiries are welcomed and should be addressed to Dr Vasanta Subramanian, .

Formal applications should be made via the University of Bath’s online application form for a PhD in Biochemistry:

Please ensure that you quote the supervisor’s name and project title in the ‘Your research interests’ section.

More information about applying for a PhD at Bath may be found here:

Anticipated start date: 28 September 2020 (an earlier start date is possible by arrangement with the lead supervisor).

Funding Notes

UK and EU citizens applying for this project may be considered for a 3-year studentship funded by the dementia charity, BRACE. The studentship will cover Home tuition fees, a stipend at the UKRI rate (£15,009 in 2019-20) and a generous budget of £10,000 per annum for research expenses and training.

Unfortunately, applicants classed as Overseas for fee-paying purposes are not eligible for the studentship.

How good is research at University of Bath in Biological Sciences?

FTE Category A staff submitted: 24.50

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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