About the Project
Training/techniques to be provided:
The mRNA and miRNA analyses will be carried over in Dr. Kurinna lab, where the candidate will also learn cloning of 3’UTRs into dual-Glo reporter vectors, luciferase assays, and mammalian tissue culture technics. The training will include high-resolution microscopy (core facilities, UoM), quantitative PCR, and protein analysis. PhD candidate will be presenting and discussing results of experiments at joint group meetings and local conferences in the form of oral and poster presentations. At the end of the project, the candidate is strongly encouraged to write a short research paper and submit it to a relevant peer-reviewed journal.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in molecular biology and tissue culture are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
2. Opalinska J: Nucleic acid drugs in the clinic. Expert Opin Drug Discov 2007, 2:321-333.
3. Kurinna S, Schafer M, Ostano P, Karouzakis E, Chiorino G, Bloch W, Bachmann A, Gay S, Garrod D, Lefort K, et al: A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes. Nat Commun 2014, 5:5099.
4. Almquist BD, Castleberry SA, Sun JB, Lu AY, Hammond PT: Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo. Adv Healthc Mater 2015.
5. Imig J, Brunschweiger A, Brummer A, Guennewig B, Mittal N, Kishore S, Tsikrika P, Gerber AP, Zavolan M, Hall J: miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. Nat Chem Biol 2015, 11:107-114.
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