About the Project
We have developed novel inhibitors to a cancer-specific enzyme, MTHFD2, involved in nucleotide metabolism required for DNA repair. We hypothesise that MTHFD2 inhibitors will selectively kill cancer cells while non-malignant cells will be unaffected.
This project will investigate the anti-cancer effects of MTHFD2 inhibitors in combination with chemotherapeutics, in particular drugs targeting the DNA damage response in vitro and in vivo. This will identify synergistic or synthetic lethal drug combinations to guide clinical translation.
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