This project is one of 19 four year PhD Studentships funded by Medical Research Scotland (https://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and External Partner Organisation (EPO). The Studentship will provide the first-class academic and additional training provided by the EPO needed to equip the successful candidate for a science career in an increasingly competitive market.
"Targeting zDHHC enzyme interactions as a novel therapeutic strategy" to be delivered by the University of Strathclyde [Supervisors: Professor Luke Chamberlain (Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde) and Professor Nicholas Tomkinson (Pure and Applied Chemistry, University of Strathclyde)] and Genentech (https://www.gene.com/) [External Partner Organisation supervisor: Dr Rami Hannoush].
S-acylation (aka palmitoylation) is a post-translational modification that plays an essential role in the function of all physiological systems. Disruption of this process has been linked to a number of important disorders including neurodegeneration, intellectual disability, epilepsy, diabetes and cancer. This project will study the protein interactions of the zDHHC enzymes that mediate S-acylation and use the results of these analyses to develop novel chemical modulators of these enzymes. The work will advance the important frontier of next-generation therapies targeting the zDHHC family of proteins. The study will include a 3-6 month placement at Genentech (San Francisco CA).
ENQUIRIES:
Enquiries should be sent by email to Professor Luke Chamberlain:
[Email Address Removed]
APPLICATIONS:
Applicants must have obtained, or expect to obtain, a first or 2.1 UK honours degree, or equivalent for degrees obtained outside the UK, in a relevant discipline.
Applications are welcome from UK nationals as well as EU nationals that hold UK settled or pre-settled status.
Applicants should send a CV, the contact details of 2 or 3 referees (including email addresses) and a covering letter explaining your reasons for applying for this particular project by email to Professor Luke Chamberlain:
[Email Address Removed]
Please note, your application may be shared with the funders of this PhD Studentship, Medical Research Scotland and Genetech.
Interviews are expected to take place 3-4 weeks after the closing date for applications. In light of the current coronavirus situation, interviews may be conducted by video conference/conference call.
It is anticipated that the PhD Studentship will start 1 October 2021.
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