Postgrad LIVE! Study Fairs

Bristol

European Molecular Biology Laboratory (Heidelberg) Featured PhD Programmes
University of West London Featured PhD Programmes
University of Warwick Featured PhD Programmes
University of Kent Featured PhD Programmes
Karlsruhe Institute of Technology Featured PhD Programmes

Targeting senescence to ameliorate ageing and treat cancer and other diseases

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Ageing is a biological process that affects all living creatures. Despite the scientific advances of the past decades, the mechanisms that lead to ageing in humans are not fully understood. Evidence suggests that accumulation of old (senescent) cells in tissues plays a critical role in the appearance of the symptoms associated with age. Indeed, recent experiments have showed that when old cells are eliminated from tissues, fitness and lifespan increases substantially.

Our work on senescence (cellular ageing) is aimed at better understanding why organisms age and providing the basis for new treatments that could be applied to slow down and improve ageing, as well as treating those diseases in which senescence has been shown to play a role (cancer, Alzheimer’s, obesity, fibrosis, etc.) . We have identified novel markers of senescence that can be used to detect senescent cells and we are using to design targeted therapies that can be tested in vitro and in vivo, in order to define novel anti-senescent strategies that could be applied clinically.

Funding Notes

Self-Funded applicants only

References

Althubiti M, Macip S. Detection of Senescent Cells by Extracellular Markers Using a Flow Cytometry-Based Approach. Methods Mol Biol. 2017;1534:147-153.

Althubiti M, Rada M, Samuel J, Escorsa JM, Najeeb H, Lee KG, Lam KP, Jones GD, Barlev NA, Macip S. BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses. Cancer Res. 2016 Sep 15;76(18):5405-14.

Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard C, Cain K and Macip S. Characterization of novel markers of senescence and their prognostic potential in cancer. Cell Death Dis. 2014 Nov 20;5:e1528.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.