Postgrad LIVE! Study Fairs

Birmingham | Edinburgh | Liverpool | Sheffield | Southampton | Bristol

University of Liverpool Featured PhD Programmes
University of Oxford Featured PhD Programmes
University of Kent Featured PhD Programmes
University of Edinburgh Featured PhD Programmes
University College London Featured PhD Programmes

Targeting telomere maintenance pathways in cancer


Project Description

Cancer occurs through the uncontrolled division of cells. The number of times a cell can divide is limited by the length of specialised DNA sequences found at the end of chromosomes called telomeres. For a cell to become cancerous it has to stop its telomeres from shortening.

To accomplish this, cancer cells either activate an enzyme (telomerase), or they copy telomeric sequences from the end of one DNA molecule to another (the alternative lengthening of telomeres (ALT) pathway).

Importantly, it is predicted that ALT positive cancers are more susceptible to different therapeutic treatments than other cancers but to date there are no ALT-targeted therapeutics. Recent research has provided important clues as to how telomere lengthening is activated in ALT cancers. We have shown that expression of a protein ATRX, which is inactivated in most ALT cancers1, suppresses telomere lengthening in ALT cells2. This project will involve developing genetic and small molecule screens with a view to a) determine the mechanism underpinning telomere maintenance in ALT cancer and b) developing new ways to target ALT cancer cells

How good is research at University of Oxford in Clinical Medicine?

FTE Category A staff submitted: 238.51

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2018
All rights reserved.