About the Project
Osteoarthritis, autophagy, TFEB, ageing, Drug screen.
The project provides unique training opportunities in various techniques such as flow cytometry, histochemistry, confocal microscopy, RNAscope assays and cell cultures such as 2D and 3D of primary culture cells, isolation and culture of human chondrocytes and synoviocyte fibroblasts, cell line culture and animal models and finally drug screen design assay. You will benefit from the KIR’s state-of-the-art core facilities, including the osteoarthritis centre where you will have access to the highly experienced animal technicians that work on osteoarthritis. You will benefit from an international and multidisciplinary environment with world-leading specialists in arthritis and ageing research and as a member of the University of Oxford, you will have access to the most up-to-date literature and collaborations within the institution, with quick and easy access to state-of-the-art platforms and experimental expertise. You will attend regular seminars within the department and in the wider University. You will benefit from daily supervision, and you will be expected to present data regularly in lab meetings and in departmental progress report seminars and in national and international conferences. You will have the opportunity to work closely with collaborating groups in DRFZ Institute, Berlin, TIGEM Institute, Naples and The Buck Institute for ageing research, California.
2. Zang H., Alsaleh G., Feltham J., Sun Y., Riffelmacher T., Charles P., Faru Lisa., Yu Z., Mohammed S., Balabanov S., Mellor J and Simon AK. Translational control of TFEB and autophagy via eIF5Arejuvenates B cell immunity. Mol Cell. 2019.
3. Sacitharan, P. K., Lwin, S., Gharios, G. B. & Edwards, J. R. Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300. Exp Mol Med. 2018. 50, 123, doi:10.1038/s12276-018-0149-3.
4. Zheng, G. et al. TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation. Cell Death Dis. 2018. 9, 858, doi:10.1038/s41419-018-0909-y.
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